反应详情

First, a mixture of 3-hydroxy-4-methoxy benzaldehyde (25 g, 164.3 mmol), hydroxylamine hydrochloride (13.7 g, 197.2 mmol), and acetic acid sodium salt (27 g, 328.6 mmol) in acetic acid (200 ml) was refluxed overnight. After cooling, the acetic acid was evaporated under reduced pressure. Water was added to the residue and the resulting precipitate was collected by filtration. The crude product was recrystalized to give 3-hydroxy-4-methoxy benzonitrile. (23.54 g, 96%)

1. temperaturewas refluxed overnight
2. temperatureAfter cooling
3. customthe acetic acid was evaporated under reduced pressure
4. additionWater was added to the residue
5. filtrationthe resulting precipitate was collected by filtration
6. customThe crude product was recrystalized