Ammonium formate → HCID 69565791, compound

HRID 1072453Notes

Reaction equation

HRID 1072453 reaction equation
C([NH:8][C@H:9]1[CH2:13][CH2:12][C@@H:11]([C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:10]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>>[NH:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:14]([C@@H:11]2[CH2:12][CH2:13][C@H:9]([NH2:8])[CH2:10]2)=[CH:15]1

Participants

3

Reactant 2

HCID 2723923Ammonium formateHCID 69564472HCID 69564472, compound

Product 1

HCID 69565791HCID 69565791, compoundYield 90%

Procedure

This compound was prepared in the same manner as for Intermediate 20, using cis-benzyl-3-(1H-indol-3-yl)-cyclopentylamine (1.3 g, 4.48 mmol) and ammonium formate (1.6 g, 25.3 mmol) to afford 0.8 g (90%) of the desired product as a thick oil which solidified upon standing: MS (ESI) m/z 201 [M+H]+.

Sources & evidence

ORD record
ord-d79996b9555d4b2f9b7270a97349688b
Source dataset
uspto-grants-2005_06
Patent number
US06911445B2

Reaction notes

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