Pyrrolidine → HCID 131725013, compound

HRID 1072509Notes

Reaction equation

HRID 1072509 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[C:7]1[CH:12]=[CH:11][C:10]([CH:13]2[C:22]3[C:17](=[C:18]([Cl:24])[CH:19]=[C:20]([Cl:23])[CH:21]=3)[CH2:16][N:15]([CH3:25])[CH2:14]2)=[CH:9][CH:8]=1>>[ClH:23].[Cl:23][C:20]1[CH:21]=[C:22]2[C:17](=[C:18]([Cl:24])[CH:19]=1)[CH2:16][N:15]([CH3:25])[CH2:14][CH:13]2[C:10]1[CH:9]=[CH:8][C:7]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 101772114-(4-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline2×

Product 1

HCID 131725013HCID 131725013, compound

Procedure

The reaction is carried out in analogy to the method described in example 10, starting from pyrrolidine and 4-(4-bromo-phenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline (example 5, intermediate 3). The product obtained after purification by chromatography is taken up in the DMSO/acetonitrile mixture, whereupon a precipitate separates out. This is filtered off, dissolved in 2 N HCl and freeze dried, resulting in the title compound of a colorless solid.

Workup

  1. customThe product obtained
  2. customafter purification by chromatography
  3. filtrationThis is filtered off
  4. dissolutiondissolved in 2 N HCl
  5. customfreeze dried

Sources & evidence

ORD record
ord-eb200eae123e4733bca7b0795b866924
Source dataset
uspto-grants-2005_06
Patent number
US06911453B2

Reaction notes

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