HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenacyl bromide → 2-[Cyclopropyl-(2,4-dichloro-benzyl)-amino]-1-phenyl-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenacyl bromide | HCID 6259 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cyclopropyl-(2,4-dichloro-benzyl)-amine | HCID 4720306 | — |
| Reactant | 4-(4-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline | HCID 10177211 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-[Cyclopropyl-(2,4-dichloro-benzyl)-amino]-1-phenyl-ethanone | HCID 22386887 | — |
Reaction Steps
Intermediate 1 was reacted with alpha-bromoacetophenone in the presence of triethylamine in dioxane by the method described in example 1, intermediate 3. For workup, the solvent was distilled off, and the residue was taken up in ethyl acetate. It was washed twice with H2O and twice with 2 N HCl, dried with MgSO4 and concentrated. The crude product obtained in this way was reacted further without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06911453B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-8cd95def416c4b37bc619ce3bc04b26b |
| Source note | uspto-grants-2005_06 |