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Sodium ethoxide → 3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenyl]-acetamide | HCID 9902939 | — |
| 反応物 | [(4-Methanesulfonylphenyl)methyl](methyl)amine | HCID 22386825 | — |
| 生成物 | 3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline | HCID 9836194 | — |
反応手順
Acetyl was eliminated from N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenyl]-acetamide (example 34) by the method described in example 17, intermediate 1, in the presence of sodium ethanolate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06911453B2 |
| 出典データセット | uspto-grants-2005_06 |
| ORD ID | ord-e61bfa34d3e04b9180dcd7d27965d8fb |
| 出典メモ | uspto-grants-2005_06 |