HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanesulfonyl chloride → N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenyl]-ethanesulfonamide, Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanesulfonyl chloride | HCID 11667 | — |
| Reactant | 4-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline | HCID 9944394 | — |
| Reactant | [(4-Methanesulfonylphenyl)methyl](methyl)amine | HCID 22386825 | — |
| Product | N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenyl]-ethanesulfonamide, Hydrochloride | HCID 131725016 | — |
Reaction Steps
The process is analogous to the method described in example 82, starting from the compound of example 17, intermediate 1, and ethanesulfonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06911453B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-a57aa051b5bc4e60bbbe550a21f8500a |
| Source note | uspto-grants-2005_06 |