Ethanesulfonyl chloride → N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenyl]-ethanesulfonamide, Hydrochloride

HRID 1072522Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1.C[S:22]([C:25]1C=CC(CNC)=C[CH:26]=1)(=[O:24])=[O:23].C(S(Cl)(=O)=O)C>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][C:17]([NH:20][S:22]([CH2:25][CH3:26])(=[O:24])=[O:23])=[CH:16][CH:15]=1

Participants

Reactant 3

HCID 11667Ethanesulfonyl chloride

HCID 99443944-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline

HCID 22386825[(4-Methanesulfonylphenyl)methyl](methyl)amine

Product 1

HCID 131725016N-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenyl]-ethanesulfonamide, Hydrochloride

Procedure

The process is analogous to the method described in example 82, starting from the compound of example 17, intermediate 1, and ethanesulfonyl chloride.

Sources & evidence

ORD record: ord-a57aa051b5bc4e60bbbe550a21f8500a
Source dataset: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06911453B2

Reaction notes

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