反应详情

3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenylamine (600 mg, example 35) was dissolved in formic acid (2.4 ml) and kept for 15 min at reflux temperature. After standing over night an ice/water mixture was added followed by ethyl acetate and saturated sodium bicarbonate solution. The organic layer was separated and the aqueous phase was extracted 3 times with dichloromethane. The organic layers were combined, dried (magnesium sulphate), filtered and concentrated in vacuo to yield 588 mg of the title compound.

1. temperatureat reflux temperature
2. waitAfter standing over night
3. customThe organic layer was separated
4. extractionthe aqueous phase was extracted 3 times with dichloromethane
5. dry with materialdried (magnesium sulphate)
6. filtrationfiltered
7. concentrationconcentrated in vacuo