反应详情

A solution of the ester 19 (55.0 g, 0.23 mol) in THF (100 mL) was treated with a 3 N NaOH solution (110 mL, 0.25 mol) for 21 h at ambient temperature. After removal of solvents, the residue was taken up in water and ethyl ether. The phases were separated, and the aqueous phase was washed with ether (2×). The resulting aqueous phase was neutralized with a 2 N HCl solution, and the precipitate was then collected by filtration to afford the acid 20 (50.2 g, 97%) as a cream solid:

1. customAfter removal of solvents
2. customThe phases were separated
3. washthe aqueous phase was washed with ether (2×)
4. filtrationthe precipitate was then collected by filtration