反应详情

A solution of 4-{1-[3-(4-butylphenyl)propan-1-yl]-5-methyl-1H-pyrrol-2-yl}phenol (880 mg, 2.53 mmol), ethyl (S)-2-hydroxy-3-phenylpropanoate (492 mg, 2.53 mmol), triphenylphosphine (665 mg, 2.54 mmol) and diethyl azodicarboxylate (442 mg, 2.54 mmol) in toluene (30 ml) was refluxed for 20 hours under heating. The residue was poured into water, extracted with ethyl acetate, washed with saturated brine and dried over magnesium sulfate anhydride. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1) to give the object compound as an oily substance. 440 mg (yield: 33%)

1. temperatureunder heating
2. extractionextracted with ethyl acetate
3. washwashed with saturated brine
4. dry with materialdried over magnesium sulfate anhydride
5. customThe solvent was removed under reduced pressure
6. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1)
7. customto give the object compound as an oily substance