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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1072724Generated: November 3, 2026

Sodium hydroxide ethanol → Sodium (2R)-2-([4-[1-(4-pentylphenylethyl)-5-methyl-1H-pyrrol-2-yl]phenyl]oxy)-3-phenylpropanoate

https://huagongshe.com/reaction/1072724

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydroxide ethanolHCID 23692425—
Reactant(2R)-2-([4-[1-(4-Pentylphenylethyl)-5-methyl-1H-pyrrol-2-yl]phenyl]oxy)-3-phenylpropanoic acidHCID 69732371—
SolventEthanolHCID 702—
ProductSodium (2R)-2-([4-[1-(4-pentylphenylethyl)-5-methyl-1H-pyrrol-2-yl]phenyl]oxy)-3-phenylpropanoateHCID 8675977162%

Reaction Steps

To a solution of (2R)-2-([4-[1-(4-pentylphenylethyl)-5-methyl-1H-pyrrol-2-yl]phenyl]oxy)-3-phenylpropanoic acid (615 mg, 1.24 mmol) in ethanol (10 ml) was added 1N sodium hydroxide-ethanol (1.21 ml, 1.21 mmol) and the mixture was concentrated. To the residue was added hexane to give the object compound as a solid. 500 mg, (yield 62%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06911468B2
Source datasetuspto-grants-2005_06
ORD IDord-82dece998f6f4f349f6a0b29bad3969d
Source noteuspto-grants-2005_06