Sodium hydroxide ethanol → Sodium (2R)-2-([4-[1-(4-pentylphenyl)-5-methyl-1H-pyrrol-2-yl]phenyl]oxy)-3-phenylpropanoate

HRID 1072727Notes

Reaction equation

HRID 1072727 reaction equation
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([N:12]2[C:16]([CH3:17])=[CH:15][CH:14]=[C:13]2[C:18]2[CH:23]=[CH:22][C:21]([O:24][C@H:25]([CH2:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:26]([OH:28])=[O:27])=[CH:20][CH:19]=2)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[OH-].[Na+:37].C(O)C>C(O)C>[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([N:12]2[C:16]([CH3:17])=[CH:15][CH:14]=[C:13]2[C:18]2[CH:23]=[CH:22][C:21]([O:24][C@H:25]([CH2:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:26]([O-:28])=[O:27])=[CH:20][CH:19]=2)=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[Na+:37]

Participants

4

Reactant 2

HCID 23692425Sodium hydroxide ethanolHCID 69732826HCID 69732826, compound

Product 1

HCID 86759773Sodium (2R)-2-([4-[1-(4-pentylphenyl)-5-methyl-1H-pyrrol-2-yl]phenyl]oxy)-3-phenylpropanoateYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (2R)-2-([4-[1-(4-pentylphenyl)-5-methyl-1H-pyrrol-2-yl]phenyl]oxy)-3-phenylpropanoic acid (621 mg, 1.33 mmol) in ethanol (10 ml) was added 1N sodium hydroxide-ethanol solution (1.3 ml, 1.3 mmol) and the mixture was concentrated. To the residue was added hexane to give the object compound as a solid. 460 mg, (yield: 71%)

Workup

  1. concentrationthe mixture was concentrated
  2. additionTo the residue was added hexane

Sources & evidence

ORD record
ord-9f8437ac6a1f44b0a51a2320f2687028
Source dataset
uspto-grants-2005_06
Patent number
US06911468B2

Reaction notes

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