反应详情

A solution of 1-(4-benzyloxyphenyl)pentane-1,4-dione (2.00 g, 7.08 mmol), 2-(4-pentylcyclohexyl)ethylamine (1.30 g, 7.08 mmol) and p-toluenesulfonic acid monohydrate (101 mg, 0.523 mmol) in toluene (100 ml) was refluxed for 12 hours under heating using Dean-Stark's apparatus, and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=30:1) to give the object compound as an oily substance. 770 mg (yield: 25.3%)

1. temperatureunder heating
2. customthe solvent was removed under reduced pressure
3. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=30:1)
4. customto give the object compound as an oily substance