Sodium Hydroxide → HCID 86759780, compound

HRID 1072755Notes

Reaction equation

HRID 1072755 reaction equation
[OH-].[Na+:2].[CH3:3][C:4]1[N:8]([CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:15][CH:14]=2)[C:7]([C:24]2[CH:41]=[CH:40][C:27]([O:28][C@H:29]([CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:30]([OH:32])=[O:31])=[CH:26][CH:25]=2)=[CH:6][CH:5]=1>C(O)C>[CH3:3][C:4]1[N:8]([CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:15][CH:14]=2)[C:7]([C:24]2[CH:25]=[CH:26][C:27]([O:28][C@H:29]([CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:30]([O-:32])=[O:31])=[CH:40][CH:41]=2)=[CH:6][CH:5]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69731997HCID 69731997, compound

Product 1

HCID 86759780HCID 86759780, compoundYield 82.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Ethanol (6 ml) and a solution of 1N sodium hydroxide in ethanol (1.10 ml) were added to (2R)-2-(4-{5-methyl-1-[3-(4-pentylphenoxy)propyl]-1H-pyrrol-2-yl}phenoxy)-3-phenylpropanoic acid (640 mg, 1.22 mmol) and the mixture was concentrated. To the residue was added diisopropylether to give the object compound as a solid. 499 mg (yield: 82.9%)

Workup

  1. concentrationthe mixture was concentrated
  2. additionTo the residue was added diisopropylether

Sources & evidence

ORD record
ord-e0c970753b0342fc9ac70712123b6327
Source dataset
uspto-grants-2005_06
Patent number
US06911468B2

Reaction notes

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