Hydrochloric Acid → HCID 10255676, compound

Participants

Reaction Steps

The (R)-α-methylbenzylamine salt of the nitro acid from example 2 (5.0 g, 23.4 mmol) was added to a mixture of ethyl acetate (50 ml) and 2M hydrochloric acid (15 ml). The mixture was stirred vigorously for 3-4 minutes and the phases were separated. The organic layer was further washed with 2M hydrochloric acid (15 ml) and demineralised water (15 ml). The organic layer was separated and the solvent was removed in vacuo to give the title compound as a yellow oil, which rapidly crystallised on standing (3.49 g).

Provenance & Evidence