Hydrochloric Acid → HCID 10255676, compound

HRID 1072776Notes

Reaction equation

HRID 1072776 reaction equation
C[C@@H](N)C1C=CC=CC=1.C[C@@H](N)C1C=CC=CC=1.[N+:19]([CH2:22][C@:23]1([CH2:30][C:31]([OH:33])=[O:32])[CH2:29][C@@H:28]2[C@H:24]1[CH2:25][CH2:26][CH2:27]2)([O-:21])=[O:20].Cl>C(OCC)(=O)C>[N+:19]([CH2:22][C@:23]1([CH2:30][C:31]([OH:33])=[O:32])[CH2:29][C@@H:28]2[C@H:24]1[CH2:25][CH2:26][CH2:27]2)([O-:21])=[O:20]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6431891-Phenethylamine, (+)-HCID 10449552HCID 10449552, compound

Product 1

HCID 10255676HCID 10255676, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The (R)-α-methylbenzylamine salt of the nitro acid from example 2 (5.0 g, 23.4 mmol) was added to a mixture of ethyl acetate (50 ml) and 2M hydrochloric acid (15 ml). The mixture was stirred vigorously for 3-4 minutes and the phases were separated. The organic layer was further washed with 2M hydrochloric acid (15 ml) and demineralised water (15 ml). The organic layer was separated and the solvent was removed in vacuo to give the title compound as a yellow oil, which rapidly crystallised on standing (3.49 g).

Workup

  1. customthe phases were separated
  2. washThe organic layer was further washed with 2M hydrochloric acid (15 ml) and demineralised water (15 ml)
  3. customThe organic layer was separated
  4. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-aa8c84ad00e142e4a0e8adf34372da1a
Source dataset
uspto-grants-2005_06
Patent number
US06911555B2

Reaction notes

Loading…