反应详情

6-(Methoxycarbonyl)-3-methyl-1H-indazole methanol (50 ml), and concentrated sulfuric acid (0.1 ml) was added. The mixture was heated under reflux for 22 hr. After cooling, a saturated aqueous sodium hydrogencarbonate solution was added and the methanol was distilled away under reduced pressure. The residue was extracted with ethyl acetate, and the organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The drying agent was filtered off and the filtrate was concentrated under reduced pressure to give the objective compound (340 mg, 87%) as brown crystals.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 22 hr
3. temperatureAfter cooling
4. distillationthe methanol was distilled away under reduced pressure
5. extractionThe residue was extracted with ethyl acetate
6. washthe organic layer was washed with saturated brine
7. dry with materialdried over anhydrous sodium sulfate
8. filtrationThe drying agent was filtered off
9. concentrationthe filtrate was concentrated under reduced pressure