Hydrochloric Acid → HCID 22387855, compound

HRID 1072851Notes

Reaction equation

HRID 1072851 reaction equation
[Cl:1][C:2]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:3]=1[CH2:4][N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([O:17]C)=[O:16])[CH:13]=2)[C:8](=[O:19])[N:7]([CH2:20][CH3:21])[C:6]1=[O:22].[OH-].[Na+].Cl>CO>[C:15]([C:12]1[CH:13]=[C:14]2[C:9]([C:8](=[O:19])[N:7]([CH2:20][CH3:21])[C:6](=[O:22])[N:5]2[CH2:4][C:3]2[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:2]=2[Cl:1])=[CH:10][CH:11]=1)([OH:17])=[O:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22388392HCID 22388392, compound

Product 1

HCID 22387855HCID 22387855, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(2,4-Dichlorobenzyl)-3-ethyl-7-(methoxycarbonyl)-2,4(1H,3H) -quinazolinedione (2.36 g) in a mixture of a 5% aqueous sodium hydroxide solution (10 g) and methanol (30 g) was heated under reflux for 1 hr. After cooling, concentrated hydrochloric acid (3.9 g) was added to the reaction mixture and the precipitate was collected by filtration. The precipitate was washed with water (100 g) and toluene (20 ml) and dried to give the objective compound (2.27 g) as white crystals.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1 hr
  3. temperatureAfter cooling
  4. filtrationthe precipitate was collected by filtration
  5. washThe precipitate was washed with water (100 g) and toluene (20 ml)
  6. customdried

Sources & evidence

ORD record
ord-5d829d1bf76c475b8eb4d3418ddb032b
Source dataset
uspto-grants-2005_06
Patent number
US06911469B2

Reaction notes

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