Hydrochloric Acid → HCID 22388166, compound

HRID 1072855Notes

Reaction equation

HRID 1072855 reaction equation
[Cl:1][C:2]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:3]=1[CH2:4][N:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([C:16]([O:18]C)=[O:17])=[CH:11][CH:12]=2)[N:7]=[CH:6]1.[OH-].[Na+].Cl>CO>[C:16]([C:10]1[CH:9]=[C:8]2[C:13]([C:14](=[O:15])[N:5]([CH2:4][C:3]3[CH:20]=[CH:21][C:22]([Cl:24])=[CH:23][C:2]=3[Cl:1])[CH:6]=[N:7]2)=[CH:12][CH:11]=1)([OH:18])=[O:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22388175HCID 22388175, compound

Product 1

HCID 22388166HCID 22388166, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-(2,4-Dichlorobenzyl)-7-(methoxycarbonyl)-4(3H)-quinazolinone (2.00 g) in a mixture of a 5% aqueous sodium hydroxide solution (20 ml) and methanol (20 ml) was heated under reflux for 1 hr. After cooling, concentrated hydrochloric acid was added to the reaction mixture and the precipitate was collected by filtration. The precipitate was washed with water (50 g) and toluene (30 ml) and dried to give the objective compound (1.50 g) as white crystals.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1 hr
  3. temperatureAfter cooling
  4. filtrationthe precipitate was collected by filtration
  5. washThe precipitate was washed with water (50 g) and toluene (30 ml)
  6. customdried

Sources & evidence

ORD record
ord-0cc2be80a32f42868a735bffb33e68cb
Source dataset
uspto-grants-2005_06
Patent number
US06911469B2

Reaction notes

Loading…