Hydrochloric Acid → HCID 22387751, compound

HRID 1072858Notes

Reaction equation

HRID 1072858 reaction equation
Cl.C([O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[N:11]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[Cl:26])[CH2:10]2)=[O:6])C.[OH-].[Na+].Cl>C(O)C>[ClH:25].[C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[N:11]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[Cl:26])[CH2:10]2)([OH:6])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22388209HCID 22388209, compound

Product 1

HCID 22387751HCID 22387751, compoundYield 129.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

6-(Ethoxycarbonyl)-3-(2,4-dichlorobenzyl)-3,4-dihydro-2-methylquinazoline hydrochloride (0.68 g) in a mixture of a 10% aqueous sodium hydroxide solution (5 ml) and ethanol (10 ml) was stirred at 60° C. for 1 hr. After standing cool the reaction mixture, concentrated hydrochloric acid (5 ml) was added and the precipitate was collected by filtration. The precipitated was washed with toluene and 2-propanol and dried to give the objective compound (0.41 g) as white crystals.

Workup

  1. additionwas added
  2. filtrationthe precipitate was collected by filtration
  3. washThe precipitated was washed with toluene and 2-propanol
  4. customdried

Sources & evidence

ORD record
ord-16f4f57f6295490091dcf07793a69164
Source dataset
uspto-grants-2005_06
Patent number
US06911469B2

Reaction notes

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