Hydrochloric Acid → HCID 22388315, compound

HRID 1072861Notes

Reaction equation

HRID 1072861 reaction equation
[C:1]([N:4]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=1[Cl:27])[C:5]1[CH:14]=[C:13]([C:15]([O:17]C)=[O:16])[CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8])(=[O:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([N:4]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=1[Cl:27])[C:5]1[CH:14]=[C:13]([C:15]([OH:17])=[O:16])[CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22388493HCID 22388493, compound

Product 1

HCID 22388315HCID 22388315, compoundYield 97.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of dimethyl 2-((N-acetyl)-(2,4-dichlorobenzyl)amino)terephthalate (2.05 g) and 10% aqueous sodium hydroxide solution (8.00 g) in methanol (20 ml) was heated at 60° C. for 1 hr. After cooling, concentrated hydrochloric acid was added to acidify the reaction mixture and the precipitated solid was collected by filtration. The solid was washed with water (60 ml) and dried to give the objective compound (1.87 g) as white crystals.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid was collected by filtration
  3. washThe solid was washed with water (60 ml)
  4. customdried

Sources & evidence

ORD record
ord-1c58b69a906f4497a4427de60612c6d9
Source dataset
uspto-grants-2005_06
Patent number
US06911469B2

Reaction notes

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