Hydrochloric Acid → HCID 22387981, compound

HRID 1072869Notes

Reaction equation

HRID 1072869 reaction equation
[Cl:1][C:2]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:3]=1[CH2:4][N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([O:17]CC)=[O:16])[CH:13]=2)[N:8]=[C:7]([CH3:20])[C:6]1=[O:21].[OH-].[Na+].CO.Cl>O>[C:15]([C:12]1[CH:13]=[C:14]2[C:9]([N:8]=[C:7]([CH3:20])[C:6](=[O:21])[N:5]2[CH2:4][C:3]2[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:2]=2[Cl:1])=[CH:10][CH:11]=1)([OH:17])=[O:16]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 22388504HCID 22388504, compound

Product 1

HCID 22387981HCID 22387981, compoundYield 77.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-(2,4-Dichlorobenzyl)-7-(ethoxycarbonyl)-3-methyl-2(1H)-quinoxalinone (0.50 g) in a mixture of a 5% aqueous sodium hydroxide solution (3 g) and methanol (20 ml) was heated under reflux for 1 hr. After cooling, concentrated hydrochloric acid (4 ml) and water (10 ml) were added to the reaction mixture and the precipitate was collected by filtration. The precipitate was washed with water (30 g) and dried to give the object compound (0.36 g) as yellow crystals.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1 hr
  3. temperatureAfter cooling
  4. filtrationthe precipitate was collected by filtration
  5. washThe precipitate was washed with water (30 g)
  6. customdried

Sources & evidence

ORD record
ord-25043ccf9c6546449ce2c61361215f5d
Source dataset
uspto-grants-2005_06
Patent number
US06911469B2

Reaction notes

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