反应详情

温度

80 °C

A mixture of 2,7-dimethyl-1H-imidazo[4,5-b]pyridine-4-oxide (4.45 g) in chloroform (4.5 ml) and phosphorous oxychloride (25.4 ml) was stirred at 80° C. for 3 hr and concentrated to dryness under reduced pressure. The residue was poured to ice (75 g), and which was neutralized with aqueous ammonia under ice-cooling. The mixture was stirred at room temperature for 30 min and the precipitated solid was washed with water to give the objective compound (3.66 g) as a gray powder.

1. concentrationconcentrated to dryness under reduced pressure
2. additionThe residue was poured to ice (75 g), and which
3. temperaturecooling
4. stirringThe mixture was stirred at room temperature for 30 min
5. washthe precipitated solid was washed with water