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HRID1072944

反应详情

EQUATION

反应方程式

HRID 1072944 的结构方程式

REACTANTS

反应物

3
结构：CC(C)(C)N=C=O
HCID62412

tert-Butyl isocyanate

C5H9NO

结构：[N-]=C=O
HCID105034

Isocyanate

CNO-

结构：COC(=O)[C@H](O)[C@@H](N)c1ccccc1
HCID10176516

(2R,3S)-3-Phenylisoserine methyl ester

C10H13NO3

PRODUCTS

生成物

1
结构：COC(=O)C(O)C(NC(=O)NC(C)(C)C)c1ccccc1
HCID22389502

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

(2R,3S)-β-phenyl-isoserine methyl ester (4.35 g, 22 mM) is dissolved in 100 mL dry THF and the flask cooled to 0° C. To the solution is added t-butyl isocyanate (2.8 mL, 25 mM). TLC after 15 minutes shows some starting material left so another 0.5 mL of the isocyanate is added. TLC after 1 hour shows no starting material so the solvent is concentrated in vacuo leaving N-(t-butylaminocarbonyl)-β-phenyl isoserine methyl ester (3K).

WORKUP

后处理

  1. additionis added
  2. waitTLC after 1 hour shows
  3. concentrationno starting material so the solvent is concentrated in vacuo