反应详情

2.5 g (8.6 mmol) of 2-dipropylamino-8-(2-aminoethoxy)-1,2,3,4-tetrahydronaphthalene and 2.4 g (17.2 mmol) of potassium carbonate were initially introduced into 40 ml of toluene. 1.5 g (9.5 mmol) of butanesulphonyl chloride were added dropwise, and the mixture was then stirred for a further 2 h at room temperature. The mixture was then filtered and evaporated in a rotary evaporator. After chromatography on silica gel 60, 40-63 μm, using diisopropyl ether/ethanol, 3:2, the product was recrystallized from petroleum ether.

1. filtrationThe mixture was then filtered
2. customevaporated in a rotary evaporator
3. customthe product was recrystallized from petroleum ether