Methyl Isocyanate → HCID 19992425, compound

HRID 1073197Notes

Reaction equation

HRID 1073197 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[NH2:5][C:6]1[CH:25]=[CH:24][C:9]([O:10][CH2:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)[CH2:14][CH2:13]2)=[CH:8][CH:7]=1>CN(C)C=O.CO>[CH3:1][NH:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)[CH2:16][CH2:17]2)=[CH:8][CH:7]=1)=[O:4]

Participants

5

Reactant 2

HCID 12228Methyl IsocyanateHCID 19992424HCID 19992424, compound

Product 1

HCID 19992425HCID 19992425, compoundYield 46.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

Methyl isocyanate (0.18 g) was added to a stirred solution of 4-[(4-aminophenoxy)methyl]-1-[4-pyridyl]piperidine (see Preparation 4) (0.57 g) in dimethylformamide (10 ml) and the mixture was stirred at room temperature for 3 hours and then diluted with methanol (2 ml). The solid was filtered off and crystallised from methanol to give the title compound, (0.32 g), m.p. 222°-224°.

Workup

  1. filtrationThe solid was filtered off
  2. customcrystallised from methanol

Sources & evidence

ORD record
ord-8edd5b64000e4c59a7ed2f2f83fb6240
Source dataset
uspto-grants-1990_11
Patent number
US04968704

Reaction notes

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