Water → HCID 22158391, compound

HRID 1073212Notes

Reaction equation

HRID 1073212 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Br[CH2:12][C:13](=O)[CH2:14][CH3:15].O>C(C(C)=O)C>[CH2:14]([C:13]1[N:1]=[C:2]2[N:6]([CH:12]=1)[C:5]1[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=1[S:3]2)[CH3:15]

Participants

5

Reactant 3

HCID 962WaterHCID 8706Benzo(d)thiazol-2-amineHCID 131561-Bromo-2-butanone

Product 1

HCID 22158391HCID 22158391, compoundYield 110%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

After 5.40 g of 2-aminobenzothiazole and 7.52 g of 1-bromo-2-butanone were allowed to stand in 40 ml of methyl ethyl ketone at room temperature overnight, 40 ml of water was added to the reaction mixture. Methyl ethyl ketone was distilled off on a water bath of 50° C. under reduced pressure. The residue was crystallized with ether and the crystals were then taken out by filtration to give 8.0 g of 2-ethylimidazo[2,1-b]benzothiazole.

Workup

  1. distillationMethyl ethyl ketone was distilled off on a water bath of 50° C. under reduced pressure
  2. customThe residue was crystallized with ether
  3. filtrationthe crystals were then taken out by filtration

Sources & evidence

ORD record
ord-21dbc038e558491fb2098ac94a7d316a
Source dataset
uspto-grants-1990_11
Patent number
US04968708

Reaction notes

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