反应详情

To a mixture of L-cystine (12 g) and 2 molar sodium hydroxide solution (50 ml), cooled to 0°-5° C. in an ice bath, was added, dropwise, methyl isocyanate (8.55 g). The clear solution was stirred at 0° for 2 hours, and then at room temperature over night.

1. temperaturecooled to 0°-5° C. in an ice bath
2. additionwas added
3. waitat room temperature over night