HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → (R,S)-Bis-(1-methyl-2,5-dioxo-4-imidazolidinyl-methyl)-disulphide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | (-)-Cystine | HCID 67678 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | (R,S)-Bis-(1-methyl-2,5-dioxo-4-imidazolidinyl-methyl)-disulphide | HCID 88616268 | — |
Reaction Steps
To a mixture of L-cystine (12 g) and 2 molar sodium hydroxide solution (50 ml), cooled to 0°-5° C. in an ice bath, was added, dropwise, methyl isocyanate (8.55 g). The clear solution was stirred at 0° for 2 hours, and then at room temperature over night.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04968711 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-a01e2a8168c54280999c179befc67799 |
| Source note | uspto-grants-1990_11 |