Water → HCID 54452339, compound

HRID 1073237Notes

Reaction equation

HRID 1073237 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH2:7]([O:11][C:12]1[CH:13]=[C:14]([CH2:18][CH2:19][NH2:20])[CH:15]=[CH:16][CH:17]=1)[CH2:8][CH2:9][CH3:10].[CH:21]1([CH:27]=[CH:28][C:29](Cl)=[O:30])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1.O>C(#N)C>[CH:21]1([CH:27]=[CH:28][C:29]([NH:20][CH2:19][CH2:18][C:14]2[CH:15]=[CH:16][CH:17]=[C:12]([O:11][CH2:7][CH2:8][CH2:9][CH3:10])[CH:13]=2)=[O:30])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 22379525HCID 22379525, compoundHCID 566232073-Cyclohexylprop-2-enoyl chloride

Product 1

HCID 54452339HCID 54452339, compoundYield 53.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

Powdered potassium carbonate (4.5 g) was added to a solution of 2-(3-butyloxyphenyl)ethylamine (4.12 g) in acetonitrile (55 cm3). A solution of 3-cyclohexylacryloyl chloride (3.66 g) in acetonitrile (20 cm3) was added dropwise over fifteen minutes and the reaction mixture was then stirred at room temperature for 2 hours. Following treatment with distilled water (75 cm3) and SVM (3 cm3), a white precipitate was formed. This was filtered off and sucked dry to give the product (3.76 g) m.p. 67°-71° C.

Workup

  1. customa white precipitate was formed
  2. filtrationThis was filtered off
  3. customsucked dry

Sources & evidence

ORD record
ord-5c6a70e8f6dc4ebaa3e90d9800e5d04e
Source dataset
uspto-grants-1990_11
Patent number
US04968698

Reaction notes

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