反应详情

To a solution of 2-[3-benzyloxyphenyl]ethylamine (2.3 g) (prepared in a manner analogous to that described in Example 1E) in acetonitrile (25 cm3) was added powdered potassium carbonate (2.1 g) followed by 3-cyclohexylpropenoyl chloride (1.72 g) in acetonitrile (10 cm3) which was added over ten minutes. The resulting mixture was stirred for one hour and was then treated with water (40 cm3) and SVM (3 cm3) thereby causing the precipitation of an oil which solidified to give a pale tan solid after several minutes. This solid was filtered off, washed with 5% SVM in water and sucked dry. Yield=3.08 g m.p. 98°-100° C.

1. additionwas added over ten minutes
2. customthe precipitation of an oil which
3. customto give a pale tan solid after several minutes
4. filtrationThis solid was filtered off
5. washwashed with 5% SVM in water
6. customsucked dry