2-(4-Chlorophenyl)ethyl chloride → 5-[(4-Chlorophenethyl)-methylamino]-2-(3,5-dimethoxyphenyl)-2-isopropylvaleronitrile

HRID 1073248Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1073248
[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][C:6]([C:12]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[C:14]([O:20][CH3:21])[CH:13]=1)([CH:9]([CH3:11])[CH3:10])[C:7]#[N:8].[Cl:22][C:23]1[CH:31]=[CH:30][C:26]([CH2:27][CH2:28]Cl)=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:31]=[CH:30][C:26]([CH2:27][CH2:28][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][C:6]([C:12]2[CH:13]=[C:14]([O:20][CH3:21])[CH:15]=[C:16]([O:18][CH3:19])[CH:17]=2)([CH:9]([CH3:11])[CH3:10])[C:7]#[N:8])=[CH:25][CH:24]=1

Komponenten

3

Edukt 2

HCID 37903592-(4-Chlorophenyl)ethyl chlorideHCID 221584772-(3,5-Dimethoxyphenyl)-2-isopropyl-5-methylaminovaleronitrile

Produkt 1

HCID 139233805-[(4-Chlorophenethyl)-methylamino]-2-(3,5-dimethoxyphenyl)-2-isopropylvaleronitrileAusbeute 65 %

Versuchsvorschrift

29.0 g (0.1 mole) of 5-methylamino-2-(3,5-dimethoxyphenyl)-2-isopropylvaleronitrile and 21.0 g (0.12 mole) of 4-chlorophenethyl chloride were reacted similarly to Example 5, and 27.9 g (60%) of base were isolated after chromatographic purification. The base was converted to the amidosulfonate. Mp. 122°-123° C.

Quellen und Nachweise

ORD-Eintrag
ord-0f36272c78d24f45bdb8711aa189d8d2
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04968717

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