HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Chlorophenyl)ethyl chloride → 5-[(4-Chlorophenethyl)-methylamino]-2-(3,5-dimethoxyphenyl)-2-isopropylvaleronitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Chlorophenyl)ethyl chloride | HCID 3790359 | — |
| Reactant | 2-(3,5-Dimethoxyphenyl)-2-isopropyl-5-methylaminovaleronitrile | HCID 22158477 | — |
| Product | 5-[(4-Chlorophenethyl)-methylamino]-2-(3,5-dimethoxyphenyl)-2-isopropylvaleronitrile | HCID 13923380 | 65% |
Reaction Steps
29.0 g (0.1 mole) of 5-methylamino-2-(3,5-dimethoxyphenyl)-2-isopropylvaleronitrile and 21.0 g (0.12 mole) of 4-chlorophenethyl chloride were reacted similarly to Example 5, and 27.9 g (60%) of base were isolated after chromatographic purification. The base was converted to the amidosulfonate. Mp. 122°-123° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04968717 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-0f36272c78d24f45bdb8711aa189d8d2 |
| Source note | uspto-grants-1990_11 |