反应详情

A 12.63 g portion of 2-amino-4'-phenylacetophenone, hydrochloride was dissolved in a mixture of 168 ml of absolute ethanol:water (1:1) and 40 ml of tetrahydrofuran. This solution was kept warm and with stirring, added dropwise to the 5-ethylisatin solution over 2 hours. The mixture was refluxed for 2 hours, then the solvent was distilled off at 85° C. and the reaction cooled for 1 hour. The red solids were collected, stirred with 2 liters of water for 1.5 hours and then filtered. The filtrate was acidified to pH 5 with glacial acetic acid. The resulting yellow solids were collected and dried, giving 4.47 g of the desired product, mp 240°-241° C.

1. temperatureThis solution was kept warm
2. temperatureThe mixture was refluxed for 2 hours
3. distillationthe solvent was distilled off at 85° C.
4. temperaturethe reaction cooled for 1 hour
5. customThe red solids were collected
6. stirringstirred with 2 liters of water for 1.5 hours
7. filtrationfiltered
8. customThe resulting yellow solids were collected
9. customdried