HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3--Amino-6-trifluoromethyl-2-(2'-fluoro[1,1'-biphenyl]-4-vl)-4-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-(trifluoromethyl)-2,3-dihydro-1H-indole-2,3-dione | HCID 12351496 | — |
| Reactant | 2-Amino-1-(2'-fluoro[1,1'-biphenyl]-4-yl)-ethanone hydrochloride | HCID 22158351 | — |
| Product | 3--Amino-6-trifluoromethyl-2-(2'-fluoro[1,1'-biphenyl]-4-vl)-4-quinolinecarboxylic acid | HCID 15085968 | — |
Reaction Steps
A solution of 6.45 g of 5-triflouromethylisatin in water was reacted with 7.97 g of 2-amino-1-(2'-fluoro[1,1'-biphenyl]-4-yl)-ethanone hydrochloride (example 17) by the procedure described in example 18, giving 9.0 g of the desired compound as a yellow solid, mp 255°-260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04968702 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-aa4f02af4a0149f890b7dc9413926264 |
| Source note | uspto-grants-1990_11 |