Water → HCID 15085979, compound

HRID 1073280Notes

Reaction equation

HRID 1073280 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O.Cl.[NH2:14][CH2:15][C:16]([C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=2[F:31])=[CH:20][CH:19]=1)=O.[OH2:32]>>[NH2:14][C:15]1[C:16]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=3[F:31])=[CH:20][CH:19]=2)=[N:7][C:8]2[C:4]([C:5]=1[C:6]([OH:11])=[O:32])=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=2

Participants

4

Reactant 3

HCID 962WaterHCID 872035-chloro-1H-indole-2,3-dioneHCID 22158352HCID 22158352, compound

Product 1

HCID 15085979HCID 15085979, compound

Procedure

A basic aqueous solution of 4.3 g of 5-chloroisatin in water was reacted with 9.4 g of 2-amino-1-(2',4'-difluoro[1,1'-biphenyl]-4-yl)ethanone hydrochloride by the procedure described in example 20, giving 6.1 g of the desired compound as a yellow solid, mp 253°-254° C.

Sources & evidence

ORD record
ord-4aab015f6c204e33ad92788f80d5a5e1
Source dataset
uspto-grants-1990_11
Patent number
US04968702

Reaction notes

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