Water → HCID 15085980, compound

HRID 1073281Notes

Reaction equation

[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=O)[C:2]1=[O:3].Cl.[NH2:13][CH2:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=2[F:30])=[CH:19][CH:18]=1)=O.[OH2:31]>>[NH2:13][C:14]1[C:15]([C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[F:30])=[CH:19][CH:18]=2)=[N:1][C:11]2[C:6]([C:4]=1[C:2]([OH:31])=[O:3])=[CH:7][CH:8]=[CH:9][CH:10]=2

Participants

Reactant 3

HCID 962Water

HCID 7054Isatin

HCID 22158352HCID 22158352, compound

Product 1

HCID 15085980HCID 15085980, compound

Procedure

A basic aqueous solution of 3.5 g of isatin in water was reacted with 9.3 g of 2-amino-1-(2',4'-difluoro[1,1'-biphenyl]-4-yl)ethanone hydrochloride by the procedure described in example 20, giving 2.8 g of the desired compound as a yellow solid, mp 244°-247° C.

Sources & evidence

ORD record: ord-f34d289613c647d8a7548da817b1dc52
Source dataset: uspto-grants-1990_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04968702

Reaction notes

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