反应详情

The above crude (3S)-3-aminopyrrolidine (200 mg) and L(+)-tartaric acid (348 mg) are dissolved in water (2 ml), and thereto is added methanol (10 ml), and the mixture is allowed to stand at room temperature for one hour to precipitate an oily substance. The superfluid is removed by decantation, and the oily substance is dissolved in a mixed solvent of methanol-water (1:1) with heating, and then the mixture is cooled, and the precipitated impurities are removed by filtration. The filtrate is concentrated to dryness, and the residue is recrystallized from a mixed solvent of methanol-water (2:3) to give (3S)-3-aminopyrrolidine L(+)-tartrate (210 mg).

1. customto precipitate an oily substance
2. customThe superfluid is removed by decantation
3. dissolutionthe oily substance is dissolved in a mixed solvent of methanol-water (1:1)
4. temperaturewith heating
5. temperaturethe mixture is cooled
6. customthe precipitated impurities are removed by filtration
7. concentrationThe filtrate is concentrated to dryness
8. customthe residue is recrystallized from a mixed solvent of methanol-water (2:3)