HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1073388Generated: October 27, 2026
1-Bromo-2-methylpropane → 5-Hydroxy-7-isobutoxy-2,2-dimethyl-4-chromanone
https://huagongshe.com/reaction/1073388
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-2-methylpropane | HCID 6555 | — |
| Reactant | Diglyme | HCID 8150 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5,7-Dihydroxy-2,2-dimethylchroman-4-one | HCID 821362 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Product | 5-Hydroxy-7-isobutoxy-2,2-dimethyl-4-chromanone | HCID 14592961 | 79% |
Reaction Steps
In 50 of diethylene glycol dimethylether (DIGLIM) 4.2 g (20 millimoles) of 5,7-dihydroxy-2,2-dimethyl-4-chromanone are dissolved, whereupon 3.0 g (22 millimoles) of potassium carbonate and 0.2 g of potassium iodide and thereafter 3.3 g (2.6 ml, 24 millimoles) of isobutyl bromide are added. The reaction mixture is heated at 100° C. for 10 hours and worked up according to Example 19. Thus 4.1 g of the desired compound are obtained, yield 79%. Mp.: 77°-79° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04968819 |
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| Source dataset | uspto-grants-1990_11 |
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| ORD ID | ord-c5d00944bab14d8da2368cff68302686 |
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| Source note | uspto-grants-1990_11 |
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