HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1073460Generated: October 26, 2026
1-O-hexadecyl-2-O-methylglycerol → 3-(Hexadecyloxy)-2-methoxypropyl phenyl phosphorochloridate
https://huagongshe.com/reaction/1073460
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-O-hexadecyl-2-O-methylglycerol | HCID 1380 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Phosphorodichloridic acid, phenyl ester | HCID 13038 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-(Hexadecyloxy)-2-methoxypropyl phenyl phosphorochloridate | HCID 22158627 | — |
Reaction Steps
A 1 mmol portion of 3-(hexadecyloxy)-2-methoxy propanol is added to a 0°-5° C. solution of 1 mmol of phenyl dichlorophosphate in 2 ml of anhydrous dichloromethane containing 1.2 mmol of triethylamine. The mixture is stirred under argon for 1 hour at 5° C., then for 2.5 hours at room temperature and then used as is.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04968790 |
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| Source dataset | uspto-grants-1990_11 |
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| ORD ID | ord-2c6ff3b38cb74657812fe94e3396e1f8 |
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| Source note | uspto-grants-1990_11 |
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