HCID 14368951, compound → HCID 22157532, compound

HRID 1073498Notes

Reaction equation

HRID 1073498 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH:12]([CH2:14][N:15]3[CH2:20][CH2:19][CH:18]([CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:17][CH2:16]3)[O:11][C:10]2=[O:28])=[CH:5][CH:4]=1>ClCCCl>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH:12]([CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:19][CH2:20]3)[O:11][C:10]2=[O:28])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 14368951HCID 14368951, compound

Product 1

HCID 22157532HCID 22157532, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent2×

Procedure

A suspension of 3.8 g of 3-p-methoxyphenyl-5-(4-benzyl-piperidino-methyl)-oxazolidin-2-one in 50 ml of 1,2-dichloroethane is added dropwise to a boiling solution of 15.6 g of dimethyl sulfide/boron tribromide complex in 50 ml of 1,2-dichloroethane; the mixture is boiled for another 30 minutes and worked up in a conventional manner to give 3-p-hydroxyphenyl-5-(4-benzyl-piperidino-methyl)-oxazolidin-2-one.

Sources & evidence

ORD record
ord-5a5362621c434034a6dcda600633751c
Source dataset
uspto-grants-1990_11
Patent number
US04970217

Reaction notes

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