Benzaldehyde → HCID 2825753, compound

HRID 1073510Notes

Reaction equation

HRID 1073510 reaction equation
[NH2:1][C@@H:2]([C:7]([OH:9])=[O:8])[C:3]([SH:6])([CH3:5])[CH3:4].[CH:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[CH3:4][C:3]1([CH3:5])[S:6][CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:1][C@H:2]1[C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 5852Penicillamine

Product 1

HCID 2825753HCID 2825753, compoundYield 94.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 250 mL flask was charged with 20 mL of water and 2.0 g (13.4 mmol) of D-penicillamine. To the resulting colorless solution was added 1.4 g (13.3 mmol) of benzaldehyde dropwise over 2 minutes. The resulting suspension was stirred vigorously for 30 minutes and allowed to stand at room temperature overnight. The solids thus obtained were collected by filtration to yield 3.0 g (12.6 mmol) of the title thiazolidine.

Workup

  1. waitto stand at room temperature overnight
  2. customThe solids thus obtained
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-38a0f51bf0b94c9a90207184b9aece46
Source dataset
uspto-grants-1990_11
Patent number
US04970221

Reaction notes

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