Phenylacetaldehyde → HCID 15097679, compound

HRID 1073511Notes

Reaction equation

HRID 1073511 reaction equation
[NH2:1][C@@H:2]([C:7]([OH:9])=[O:8])[C:3]([SH:6])([CH3:5])[CH3:4].[C:10]1([CH2:16][CH:17]=O)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>O>[CH3:4][C:3]1([CH3:5])[S:6][CH:17]([CH2:16][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:1][C@H:2]1[C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 998PhenylacetaldehydeHCID 5852Penicillamine

Product 1

HCID 15097679HCID 15097679, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 250 mL flask was charged with 20 mL of water and 2.0 g (13.4 mmol) of D-penicillamine. To the resulting colorless solution was added 1.6 g (13.3 mmol) of phenyl acetaldehyde dropwise over 2 minutes. The suspension obtained was stirred vigorously for 30 minutes and allowed to stand at room temperature overnight. The solids were collected by suction filtration to yield the crude title thiazolidine which was carried on without further purification.

Workup

  1. customThe suspension obtained
  2. waitto stand at room temperature overnight
  3. filtrationThe solids were collected by suction filtration

Sources & evidence

ORD record
ord-a561eb1f867c4dcd8bf85cd83704325b
Source dataset
uspto-grants-1990_11
Patent number
US04970221

Reaction notes

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