反应详情

A mixture of 4-(3,5-difluorophenoxy)anisole (22.0 g, 0.093 mol), acetic acid (200 ml) and a 47% aqueous hydrogen bromide solution (200 ml) was heated with stirring under reflux for 8 hours. After allowed to cool, the reaction mixture was poured into ice-water and extracted with a mixture of ether and n-hexane (1 : 2). The organic layer was washed with water three times and dried over anhydrous magnesium sulfate. Removal of the solvent gave 4-(3,5-difluorophenoxy)phenol (20.27 g).

1. temperatureunder reflux for 8 hours
2. temperatureto cool
3. extractionextracted with a mixture of ether and n-hexane (1 : 2)
4. washThe organic layer was washed with water three times
5. dry with materialdried over anhydrous magnesium sulfate
6. customRemoval of the solvent