反应详情

The thus obtained ethyl 2-[4-(3,5-difluorophenoxy)phenoxy]propionate (15.6 g) was dissolved in diethyl ether (10 ml). The resulting solution was dropwise added to a suspension of lithium aluminum hydride (1.38 g, 36.3 mmol) in diethyl ether (70 ml) with stirring at an inner temperature of -20° to -10° C. After completion of the addition, stirring was continued for 1 hour while keeping the inner temperature at 0° to 5° C. The reaction mixture was poured into a mixture of ice and hydrochloric acid and extracted with ether. The ether layer was dried over anhydrous magnesium sulfate, and the solvent was removed to give 2-methyl-2-[4-(3,5-difluorophenoxy)phenoxy]ethanol (12.6 g).

1. additionAfter completion of the addition
2. stirringstirring
3. customat 0° to 5° C
4. extractionextracted with ether
5. dry with materialThe ether layer was dried over anhydrous magnesium sulfate
6. customthe solvent was removed