反应详情

温度

20 °C

A suspension of 70.4 g of 4-chloro-2-ethoxy-6,7,8-trifluoroquinoline in 170 cm3 of a 35% aqueous solution of hydrochloric acid, 420 cm3 of acetic acid and 250 cm3 of water is heated, with stirring, at a temperature close to 100° C. for 2 hours and a half. After cooling to about 20° C., the reaction mixture is poured into 1,100 cm3 of water at about 5° C., the mixture is stirred for 15 minutes at this temperature and the insoluble matter is then drained and washed with 3 times 220 cm3 of water. 61 g of 4-chloro-6,7,8-trifluorocarbostyril are obtained in the form of a cream solid melting at 213° C., which is used for the subsequent steps without further purification.

1. temperatureis heated
2. customclose to 100° C. for 2 hours
3. stirringthe mixture is stirred for 15 minutes at this temperature
4. washwashed with 3 times 220 cm3 of water