Sodium Iodide → HCID 18642030, compound

HRID 1073703Notes

Reaction equation

HRID 1073703 reaction equation
[CH3:1][C@@H:2]1[C@@:19]2([CH3:20])[C:6]([C:7](Br)([CH2:22]Br)[CH2:8][C@@H:9]3[C@@H:18]2[CH2:17][CH2:16][C@@:14]2([CH3:15])[C@H:10]3[CH2:11][CH2:12][C:13]2=[O:21])=[CH:5][C:4](=[O:25])[CH:3]1[Br:26].[I-].[Na+]>CC(C)=O>[CH3:1][C@@H:2]1[C@@:19]2([CH3:20])[C:6]([C:7](=[CH2:22])[CH2:8][C@@H:9]3[C@@H:18]2[CH2:17][CH2:16][C@@:14]2([CH3:15])[C@H:10]3[CH2:11][CH2:12][C:13]2=[O:21])=[CH:5][C:4](=[O:25])[CH:3]1[Br:26]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 53987176HCID 53987176, compound

Product 1

HCID 18642030HCID 18642030, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

With a procedure similar to the one described in the Example 3, 2.5 g of 1α-methyl-2,6-dibromo-6-bromomethylandrost-4-ene-3,17-dione and 5.5 g of sodium iodide in acetone give 1.6 g of the crude title compound which is directly used for the next step.

Sources & evidence

ORD record
ord-409cc0009b4844fdad2f0348a692b26a
Source dataset
uspto-grants-1990_11
Patent number
US04970327

Reaction notes

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