Hydrochloric Acid → HCID 178479738, compound

Participants

Reaction Steps

To a solution of (3S)-1,3-dihydro-1-(4-imidazolylmethyl) -3-(2-indolylcarbonylamino)-5-(2-fluorophenyl) -2H-1,4-benzodiazepine-2-one (215.1 mg) in methanol (5 ml) was added 6N-hydrogen chloride solution in ether (0.1 ml) under cooling. The clear yellow solution was evaporated to dryness under reduced pressure. The residue was triturated in ether to afford yellow powder, which was collected by filtration and washed twice with ether to give (3S)-1,3-dihydro-1-(4-imidazolylmethyl)-3-(2-indolylcarbonylamino) -5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-one hydrochloride (197.1 mg).

Provenance & Evidence