Hydrochloric Acid → HCID 178479738, compound

HRID 1073722Notes

Reaction equation

HRID 1073722 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][N:7]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[C:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[F:24])=[N:10][C@H:9]([NH:25][C:26]([C:28]3[NH:29][C:30]4[C:35]([CH:36]=3)=[CH:34][CH:33]=[CH:32][CH:31]=4)=[O:27])[C:8]2=[O:37])[N:3]=[CH:2]1.[ClH:38]>CO.CCOCC>[ClH:38].[NH:1]1[CH:5]=[C:4]([CH2:6][N:7]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[C:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[F:24])=[N:10][C@H:9]([NH:25][C:26]([C:28]3[NH:29][C:30]4[C:35]([CH:36]=3)=[CH:34][CH:33]=[CH:32][CH:31]=4)=[O:27])[C:8]2=[O:37])[N:3]=[CH:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178523845HCID 178523845, compound

Product 1

HCID 178479738HCID 178479738, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of (3S)-1,3-dihydro-1-(4-imidazolylmethyl) -3-(2-indolylcarbonylamino)-5-(2-fluorophenyl) -2H-1,4-benzodiazepine-2-one (215.1 mg) in methanol (5 ml) was added 6N-hydrogen chloride solution in ether (0.1 ml) under cooling. The clear yellow solution was evaporated to dryness under reduced pressure. The residue was triturated in ether to afford yellow powder, which was collected by filtration and washed twice with ether to give (3S)-1,3-dihydro-1-(4-imidazolylmethyl)-3-(2-indolylcarbonylamino) -5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-one hydrochloride (197.1 mg).

Workup

  1. temperatureunder cooling
  2. customThe clear yellow solution was evaporated to dryness under reduced pressure
  3. customThe residue was triturated in ether
  4. customto afford yellow powder, which
  5. filtrationwas collected by filtration
  6. washwashed twice with ether

Sources & evidence

ORD record
ord-898f19eb399049febc18af0021886a3b
Source dataset
uspto-grants-1990_11
Patent number
US04970207

Reaction notes

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