Water → HCID 14678270, compound

HRID 1073727Notes

Reaction equation

HRID 1073727 reaction equation
C([O:4][CH2:5][C:6]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([OH:21])[CH2:7][N:8]([S:10]([C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[CH3:20])(=[O:12])=[O:11])[CH3:9])(=O)C.C(N(CC)CC)C.O>CO>[CH3:20][C:14]1[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=1[S:10]([N:8]([CH2:7][C:6]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([OH:21])[CH2:5][OH:4])[CH3:9])(=[O:11])=[O:12]

Participants

5

Reactant 3

HCID 962WaterHCID 8471TriethylamineHCID 14678277HCID 14678277, compound

Product 1

HCID 14678270HCID 14678270, compoundYield 89.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3.50 g of 1-acetoxy-3-[N-(2,5-dimethylphenylsulfonyl)-N-methylamino]-2-phenyl-2-propanol prepared in the above-described way, 3 ml of triethylamine, 3 ml of water and 6 ml of methanol was stirred at room temperature for 4 hours. After distilling off the solvent, the residue was purified by silica gel column chromatography (developing solvent: benzene-ethyl acetate (4:1)) to obtain 2.80 g of the titled compound.

Workup

  1. distillationAfter distilling off the solvent
  2. customthe residue was purified by silica gel column chromatography (developing solvent: benzene-ethyl acetate (4:1))

Sources & evidence

ORD record
ord-7f2861ca6e2d4695b32f90d01b652415
Source dataset
uspto-grants-1990_11
Patent number
US04971620

Reaction notes

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